Researcher Information
researchmap URL
Research History
- Oct. 2024 - Mar. 2026
Japan Agency for Marine-Earth Science and Technology, Institute for Extra-cutting-edge Science and Technology Avant-garde Research (X-star), Researcher - Apr. 2021 - Sep. 2024
Japan Agency for Marine-Earth Science and Technology, Institute for Extra-cutting-edge Science and Technology Avant-garde Research, Researcher (II) - Apr. 2016 - Mar. 2021
Tokyo Institute of Technology, 情報理工学院, Assistant Professor - Apr. 2005 - Mar. 2016
Tokyo Institute of Technology, 大学院総合理工学研究科, Assistant Professor - 2004 - 2005
:東京大学 大学院情報理工学系研究科 コンピュータ科学専攻 生物情報科学学部教育特別プログラム（UPBSB） 科学技術振興特任研究員 - 2001 - 2004
:日本学術振興会 特別研究員（DC1）
Research activity information
Papers
- 竹内七海; 小宮健; 川野竜司
ナノスケールの孔で読み取るDNAコンピューティング
バイオサイエンスとインダストリー(B&I）, 16 Mar. 2026
84, 2, 150, 152
[Invited] - Daichi Iwata; Keiji Murayama; Ken Komiya; Hideaki T Matsubayashi; Keita Abe; Hiroyuki Asanuma; Satoshi Murata; Shin-Ichiro M Nomura
Reversible Photocontrol of mRNA Synthesis and Cleavage for mRNA Concentration Switching Inside Artificial Cells
ChemRxiv, 03 Mar. 2026 - Ken Komiya
Expansion of Molecular Systems Function with the Use of Artificial Nucleic Acids
Molecular Robotics II (Murata, S., Nakakuki, T., Toyota, T., Nomura, Si., Kuzuya, A. (eds)), 30 Jan. 2026
39, 45
Lead, Corresponding - 小宮 健
Revisiting Reaction Machineries of DNA Computing as a Foundation of Molecular Robotics
Journal of the Institute of Electronics, Information and Communication Engineers, Nov. 2025
108, 11, 1046, 1052
[Invited]
Lead, Corresponding - Kai Yoshida; Ryusei Kawabe; Keita Abe; Yusuke Sato; Ibuki Kawamata; ken Komiya; Richard James Archer; Hideaki T. Matsubayashi; Shogo Hamada; Satoshi Murata; Shin-ichiro Nomura
Transmembrane DNA Sequence Signaling via Hybridization
ChemRxiv, 30 Sep. 2025 - Riko Miyazaki; Kazuki Aibara; Haruhi Isse; Fumiya Kashiwai; Masashi Takahashi; Azusa Onodera; Yuji Tsunekawa; Yuko Yamauchi; Kazuto Yoshimi; Tomoji Mashimo; Ken Komiya; Takashi Okada
A Novel MiRNA Detection System Combining TWJ-SDA, Multistep L-TEAM, and CRISPR-Cas3
bioRxiv, 25 Sep. 2025 - Sotaro Takiguchi; Nanami Takeuchi; Harune Suzuki; Masayuki Ohara; Ken Komiya; Ryuji Kawano
Nanopore‐Based Single‐Molecule Logic Unit (sMOLU)
Small, 04 Jun. 2025
21, 34, 2501560
[Reviewed] - Ken Komiya; Chizuru Noda; Masayuki Yamamura
Characterization of Cascaded DNA Generation Reaction for Amplifying DNA Signal
New Generation Computing, Mar. 2024
42, 237, 252
[Reviewed]
Lead, Corresponding - Ken Komiya; Ryuma Shineha; Naoto Kawahara
Practice of responsible research and innovation in the formulation and revision of ethical principles of molecular robotics in Japan
SN Applied Sciences, Oct. 2022
4, 305
[Reviewed]
Lead, Corresponding - Ryutaro Yako; Daihei Ise; Ken Komiya; Kenzo Fujimoto; Satoshi Kobayashi
Monotone Control of R Systems
New Generation Computing, Jul. 2022
40, 2, 623, 657
[Reviewed] - Nobuya Kimoto; Shigetaka Nakamura; Ken Komiya; Kenzo Fujimoto; Satoshi Kobayashi
Reducing Control Alphabet Size for the Control of Right Linear Grammars with Unknown Behaviors
Theoretical Computer Scinece, 16 Mar. 2021
862, 193, 213
[Reviewed] - Nobuya Kimoto; Ken Komiya; Kenzo Fujimoto; Satoshi Kobayashi
Monotonically controlling right linear grammars with unknown behaviors to output a target string
Theoretical Computer Science, 19 Jul. 2019
777, 387, 408
[Reviewed] - Ken Komiya
Measurement of microRNA with isothermal DNA amplification on fully automated immunoassay analyzers
Analytical and Bioanalytical Chemistry, 03 Jun. 2019 - Yusuke Sato; Ken Komiya; Ibuki Kawamata; Satoshi Murata; Shin-ichiro M. Nomura
Isothermal amplification of specific DNA molecules inside giant unilamellar vesicles
Chemical Communications, 2019 - K. Komiya; M. Komori; C. Noda; S. Kobayashi; T. Yoshimura; M. Yamamura
Leak-free million-fold DNA amplification with locked nucleic acid and targeted hybridization in one pot
Organic & Biomolecular Chemistry, 2019 - John A. Rose; Ken Komiya; Satoshi Kobayashi
Engineering multistate DNA molecules: a tunable thermal band-pass filter
MICRO & NANO LETTERS, Oct. 2016
11, 10, 595, 601
[Reviewed] - John A. Rose; Ken Komiya
Analysis and Design of a Single-Molecule DNA Nanodevice for Thermal Band-Pass Filters
2016 IEEE 11TH ANNUAL INTERNATIONAL CONFERENCE ON NANO/MICRO ENGINEERED AND MOLECULAR SYSTEMS (NEMS), 2016
[Reviewed] - Ken Komiya; Masayuki Yamamura
Cascading DNA Generation Reaction for Controlling DNA Nanomachines at a Physiological Temperature
NEW GENERATION COMPUTING, Jul. 2015
33, 3, 213, +
[Reviewed] - Masami Hagiya; Satoshi Kobayashi; Ken Komiya; Fumiaki Tanaka; Takashi Yokomori
Molecular computing machineries-computing models and wet implementations
Handbook of Natural Computing, 01 Jan. 2012
3-4, 1130, 1184 - KOMIYA Ken; ROSE John A.; YAMAMURA Masayuki
Autonomous DNA-Molecule Computing : Towards Construction of in vitro Intelligence
計測自動制御学会論文集 = Transactions of the Society of Instrument and Control Engineers, 30 Nov. 2010
46, 11, 700, 705
[Reviewed] - Ken Komiya; Masayuki Yamamura; John A. Rose
Quantitative design and experimental validation for a single-molecule DNA nanodevice transformable among three structural states
NUCLEIC ACIDS RESEARCH, Jul. 2010
38, 13, 4539, 4546
[Reviewed] - Ken Komiya; Masayuki Yamamura; John A. Rose
Experimental Validation and Optimization of Signal Dependent Operation in Whiplash PCR
Natural Computing, 2010
9, 1, 207, 218
[Reviewed], [Invited] - Ken Komiya; Masayuki Yamamura; John A. Rose
Experimental Validation of Signal Dependent Operation in Whiplash PCR
DNA COMPUTING, 2009
5347, 1, +
[Reviewed] - Hiroyuki Sekiguchi; Ken Komiya; Daisuke Kiga; Masayuki Yamamura
Realization of DNA molecular machine that walks autonomously by using a restriction enzyme
DNA COMPUTING, 2008
4848, 54, +
[Reviewed] - Ken Komiya; Noriko Hirayama; Masayuki Yamamura
An interface for a computing model using methylation to allow precise population control by quantitative monitoring
DNA COMPUTING, 2008
4848, 191, +
[Reviewed] - Hiroyuki Sekiguchi; Ken Komiya; Daisuke Kiga; Masayuki Yamamura
A design and feasibility study of reactions comprising DNA molecular machine that walks autonomously by using a restriction enzyme
Natural Computing, 2008
7, 3, 303, 315
[Reviewed], [Invited] - Masayuki Yamamura; Noriko Hirayama; Ken Komiya
An implementation of aqueous memory molecules with light responsive DNAs
2007 IEEE CONGRESS ON EVOLUTIONARY COMPUTATION, VOLS 1-10, PROCEEDINGS, 2007
1843, +
[Reviewed] - John A. Rose; Ken Komiya; Satsuki Yaegashi; Masami Hagiya
Displacement Whiplash PCR: Optimized architecture and experimental validation
DNA Computing, 2006
4287, 393, 403
[Reviewed] - Ken Komiya; Satsuki Yaegashi; Masami Hagiya; Akira Suyama; John A. Rose
Experimental validation of the statistical thermodynamic model for prediction of the behavior of autonomous molecular computers based on DNA hairpin formation
DNA COMPUTING, 2006
4287, 428, +
[Reviewed] - K Komiya; K Sakamoto; A Kameda; M Yamamoto; A Ohuchi; D Kiga; S Yokoyama; M Hagiya
DNA polymerase programmed with a hairpin DNA incorporates a multiple-instruction architecture into molecular computing
BIOSYSTEMS, Jan. 2006
83, 1, 18, 25
[Reviewed] - M Hagiya; JA Rose; K Komiya; K Sakamoto
Complexity analysis of the SAT engine: DNA algorithms as probabilistic algorithms
THEORETICAL COMPUTER SCIENCE, Sep. 2002
287, 1, 59, 71
[Reviewed], [Invited] - Komiya, K.; Sakamoto, K.; Gouzu, H.; Yokoyama, S.; Arita, M.; Nishikawa, A.; Hagiya, M.
Successive state transitions with I/O interface by molecules
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 2001
2054, 17, 26
[Reviewed] - K Sakamoto; H Gouzu; K Komiya; D Kiga; S Yokoyama; T Yokomori; M Hagiya
Molecular computation by DNA hairpin formation
SCIENCE, May 2000
288, 5469, 1223, 1226
[Reviewed] - Masanori Arita; Akio Nishikawa; Masami Hagiya; Ken Komiya; Hidetaka Gouzu; Kensaku Sakamoto
Improving Sequence Design for DNA Computing.
Proceedings of the Genetic and Evolutionary Computation Conference (GECCO '00), Las Vegas, Nevada, USA, July 8-12, 2000, 2000
875, 882
[Reviewed] - K Sakamoto; D Kiga; K Komiya; H Gouzu; S Yokoyama; S Ikeda; H Sugiyama; M Hagiya
State transitions by molecules
BIOSYSTEMS, Oct. 1999
52, 1-3, 81, 91
[Reviewed]
Books and Other Publications
Presentations
- K. Komiya; C. Noda
Toward Evaluation of Non-Specific DNA Amplification as a Novel Information Generation Process during Isothermal Incubation
第50回 生命の起源・アストロバイオロジー学会 学術講演会, 26 Mar. 2026 - 岩田大地; 村山恵司; 小宮健; 松林英明; 安部桂太; 浅沼浩之; 村田智; 野村慎一郎
人工細胞内でのmRNA量スイッチングのためのmRNA合成と切断の可逆的な光制御
第９回分子ロボティクス年次大会, 12 Mar. 2026, [Invited] - 小宮 健; 野田 千鶴; 中茎 隆
モデル予測および実験によるカスケード型DNA生成反応のシグナル増幅性能検証
第９回分子ロボティクス年次大会, 12 Mar. 2026 - Ken Komiya; Chizuru Noda; Takashi Nakakuki
Experimental Characterization of Cascaded DNA Generation Reaction with Respect to Signal Amplification Performance
Chem-Bio Informatics Society (CBI) Annual Meeting 2025, 30 Oct. 2025 - Ken Komiya; Chizuru Noda; Takashi Nakakuki
Characterization of Responsive Nucleic Acid Amplification systems
The 63rd Annual Meeting of the Biophysical Society of Japan, 25 Sep. 2025 - Daichi Iwata; Keiji Murayama; Ken Komiya; Keita Abe; Satoshi Murata; Hideaki T. Matsubayashi; Shin-ichiro M. Nomura
Control of Gene expression in synthetic cells using photoresponsive molecular switches
The 31st International Conference on DNA Computing and Molecular Programming (DNA31), Aug. 2025 - 小宮 健
DNAコンピューティングのkiller app.を求めて： 状態遷移機械が多数並列演算する鎖置換駆動型WPCR反応をリブートする
東京科学大学 情報理工学院 情報工学系 山村雅幸研究室セミナー, 24 Jun. 2025 - 竹内七海; 鈴木春音; 小宮健; 川野竜司
腫瘍由来核酸検出・自律型薬剤生成リポソーム型分子ロボットの細胞作用評価
化学とマイクロ・ナノシステム学会 第51回研究会（Cheminas51）, 16 May 2025 - Nanami Takeuchi; Harune Suzuki; Ken Komiya; Ryuji Kawano
DNA computing–based liposomes for miR-20a detection and antisense oligonucleotide generation in living cell environments
Foundations of Nanoscience 22nd Annual Conference (FNANO2025), 29 Apr. 2025 - Experimental Validation of Signal Dependent Operation in Whiplash PCR
Fourteenth International Meeting on DNA Based Computers (DNA14), 2009 - Experimental Validation of Signal Dependent Operation in Whiplash PCR
Fourteenth International Meeting on DNA Based Computers (DNA14), 2009 - 自律DNA分子計算 ‐ in vitro インテリジェンスの構築
システム・情報部門 学術講演会 2009 (SSI2009), 2009 - A realization of DNA molecular machine that walks autonomously by using a restriction enzyme
Thirteenth International Meeting on DNA Based Computers (DNA13), 2008 - An Interface for a Computing Model Using Methylation to Allow Precise Population Control by Quantitative Monitoring
Thirteenth International Meeting on DNA Based Computers (DNA13), 2008 - A realization of DNA molecular machine that walks autonomously by using a restriction enzyme
Thirteenth International Meeting on DNA Based Computers (DNA13), 2008 - An Interface for a Computing Model Using Methylation to Allow Precise Population Control by Quantitative Monitoring
Thirteenth International Meeting on DNA Based Computers (DNA13), 2008 - An Implementation of Aqueous Memory Molecules with Light Responsive DNAs
2007 IEEE Congress on Evolutionary Computation (CEC2007), 2007 - An Implementation of Aqueous Memory Molecules with Light Responsive DNAs
2007 IEEE Congress on Evolutionary Computation (CEC2007), 2007 - Experimental Validation of the Statistical Thermodynamic Model for Prediction of the Behavior of Autonomous Molecular Computers Based on DNA Hairpin Formation
Twelfth International Meeting on DNA Based Computer (DNA12), 2006 - Displacement Whiplash PCR: Optimized Architecture and Experimental Validation
Twelfth International Meeting on DNA Based Computer (DNA12), 2006 - Experimental Validation of the Statistical Thermodynamic Model for Prediction of the Behavior of Autonomous Molecular Computers Based on DNA Hairpin Formation
Twelfth International Meeting on DNA Based Computer (DNA12), 2006 - Displacement Whiplash PCR: Optimized Architecture and Experimental Validation
Twelfth International Meeting on DNA Based Computer (DNA12), 2006 - Branching DNA Machines Based on Transitions of Hairpin Structures
2003 Congress on Evolutionary Computation (CEC2003), 2003 - Branching DNA Machines Based on Transitions of Hairpin Structures
2003 Congress on Evolutionary Computation (CEC2003), 2003 - Successive State Transitions with I/O Interface by Molecules
Sixth International Meeting on DNA Based Computers (DNA6), 2001 - Successive State Transitions with I/O Interface by Molecules
Sixth International Meeting on DNA Based Computers (DNA6), 2001 - Improving Sequence Design for DNA Computing
Fifth Genetic and Evolutionary Computation Conference (GECCO2000), 2000 - Improving Sequence Design for DNA Computing
Fifth Genetic and Evolutionary Computation Conference (GECCO2000), 2000 - SAT Engineの計算量の解析 竏抽m率アルゴリズムとしてのDNAアルゴリズム竏驤
新しい計算パラダイムシンポジウム2000, 2000 - DNA分子の自己会合反応の解析
新しい計算パラダイムシンポジウム2000, 2000 - State Transitions by Molecules
Fourth International Meeting on DNA Based Computers (DNA4), 1999 - State Transitions by Molecules
Fourth International Meeting on DNA Based Computers (DNA4), 1999 - Komiya K.; Kiga D.; Gozu H.; Nishikawa A.; Sakamoto K.; Yokoyama S.; Hagiya M.
Implementations by DNA molecules-DNA computing.
Biophysics, 07 Sep. 1998
